Ontology highlight
ABSTRACT:
SUBMITTER: Biber K
PROVIDER: S-EPMC3101996 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Biber Knut K Tsuda Makoto M Tozaki-Saitoh Hidetoshi H Tsukamoto Keiko K Toyomitsu Emika E Masuda Takahiro T Boddeke Hendrikus H Inoue Kazuhide K
The EMBO journal 20110325 9
Up-regulation of P2X4 receptors in spinal cord microglia is crucial for tactile allodynia, an untreatable pathological pain reaction occurring after peripheral nerve injury. How nerve injury in the periphery leads to this microglia reaction in the dorsal horn of the spinal cord is not yet understood. It is shown here that CCL21 was rapidly expressed in injured small-sized primary sensory neurons and transported to their central terminals in the dorsal horn. Intrathecal administration of a CCL21- ...[more]