P2X4 receptor regulates alcohol-induced responses in microglia.
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ABSTRACT:
SUBMITTER: Gofman L
PROVIDER: S-EPMC4209197 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
P2X4 receptor regulates alcohol-induced responses in microglia.
Gofman Larisa L Cenna Jonathan M JM Potula Raghava R
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20140820 5
Mounting evidence indicates that alcohol-induced neuropathology may result from multicellular responses in which microglia cells play a prominent role. Purinergic receptor signaling plays a key role in regulating microglial function and, more importantly, mediates alcohol-induced effects. Our findings demonstrate that alcohol increases expression of P2X4 receptor (P2X4R), which alters the function of microglia, including calcium mobilization, migration and phagocytosis. Our results show a signif ...[more]
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