Ontology highlight
ABSTRACT:
SUBMITTER: Santaguida S
PROVIDER: S-EPMC3102279 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Santaguida Stefano S Vernieri Claudio C Villa Fabrizio F Ciliberto Andrea A Musacchio Andrea A
The EMBO journal 20110315 8
Fidelity of chromosome segregation is ensured by a tension-dependent error correction system that prevents stabilization of incorrect chromosome-microtubule attachments. Unattached or incorrectly attached chromosomes also activate the spindle assembly checkpoint, thus delaying mitotic exit until all chromosomes are bioriented. The Aurora B kinase is widely recognized as a component of error correction. Conversely, its role in the checkpoint is controversial. Here, we report an analysis of the ro ...[more]