Ontology highlight
ABSTRACT:
SUBMITTER: Ye AA
PROVIDER: S-EPMC4509859 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Ye Anna A AA Deretic Jovana J Hoel Christopher M CM Hinman Albert W AW Cimini Daniela D Welburn Julie P JP Maresca Thomas J TJ
Current biology : CB 20150709 14
Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from opposing spindle poles, is the configuration that best ensures equal partitioning of the genome during cell division. Erroneous kinetochore-MT attachments are commonplace but are often corrected prior to anaphase. Error correction, thought to be mediated primarily by the centromere-enriched Aurora B kinase (ABK), typically occurs near spindle poles; however, the relevance of this locale is unclear. Furthermore, ...[more]