Ontology highlight
ABSTRACT:
SUBMITTER: Annala M
PROVIDER: S-EPMC3102690 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Annala Matti M Laurila Kirsti K Lähdesmäki Harri H Nykter Matti M
PloS one 20110526 5
Protein binding microarrays (PBM) are a high throughput technology used to characterize protein-DNA binding. The arrays measure a protein's affinity toward thousands of double-stranded DNA sequences at once, producing a comprehensive binding specificity catalog. We present a linear model for predicting the binding affinity of a protein toward DNA sequences based on PBM data. Our model represents the measured intensity of an individual probe as a sum of the binding affinity contributions of the p ...[more]