Ontology highlight
ABSTRACT:
SUBMITTER: Berger MF
PROVIDER: S-EPMC4419707 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Berger Michael F MF Philippakis Anthony A AA Qureshi Aaron M AM He Fangxue S FS Estep Preston W PW Bulyk Martha L ML
Nature biotechnology 20060924 11
Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene expression throughout myriad cellular processes. However, the DNA binding specificities of only a small fraction of TFs are sufficiently characterized to predict the sequences that they can and cannot bind. We present a maximally compact, synthetic DNA sequence design for protein binding microarray (PBM) experiments that represents all possible DNA sequence variants of a given length k (that is, all 'k-me ...[more]