Ontology highlight
ABSTRACT:
SUBMITTER: Lee HH
PROVIDER: S-EPMC3102766 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Lee Henry H C HH Deeb Tarek Z TZ Walker Joshua A JA Davies Paul A PA Moss Stephen J SJ
Nature neuroscience 20110501 6
KCC2 is a neuron-specific K(+)-Cl(-) co-transporter that maintains a low intracellular Cl(-) concentration that is essential for hyperpolarizing inhibition mediated by GABA(A) receptors. Deficits in KCC2 activity occur in disease states associated with pathophysiological glutamate release. However, the mechanisms by which elevated glutamate alters KCC2 function are unknown. The phosphorylation of KCC2 residue Ser940 is known to regulate its surface activity. We found that NMDA receptor activity ...[more]