Ontology highlight
ABSTRACT:
SUBMITTER: Laederich MB
PROVIDER: S-EPMC3103339 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Laederich Melanie B MB Degnin Catherine R CR Lunstrum Gregory P GP Holden Paul P Horton William A WA
The Journal of biological chemistry 20110412 22
Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of growth and differentiation, whose aberrant activation causes a number of genetic diseases including achondroplasia and cancer. Hsp90 is a specialized molecular chaperone involved in stabilizing a select set of proteins termed clients. Here, we delineate the relationship of Hsp90 and co-chaperone Cdc37 with FGFR3 and the FGFR family. FGFR3 strongly associates with these chaperone complexes and depends on them for stability and func ...[more]