Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines.
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ABSTRACT:
SUBMITTER: Chavez KJ
PROVIDER: S-EPMC3103647 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
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Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines.
Chavez Kathryn J KJ Feng Xiaohong X Flanders James A JA Rodriguez Eloy E Schroeder Frank C FC
Journal of natural products 20110310 5
We investigated the composition of extracts derived from Guaiacum spp. (Zygophyllaceae), a group of neotropical tree species with varied uses in Central and South American traditional medicine. Activity-guided fractionation of Guaiacum heartwood extracts led to the identification of four new spirocyclic lignans, named ramonanins A-D (1-4). The ramonanins exhibit cytotoxic activity against human breast cancer cell lines with an IC50 value of 18 μM and induce cell death via apoptotic mechanisms. T ...[more]
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