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Reevaluating the role of LTD in cerebellar motor learning.

ABSTRACT: Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or ?CamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.

SUBMITTER: Schonewille M

PROVIDER: S-EPMC3104468 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Reevaluating the role of LTD in cerebellar motor learning.

Schonewille Martijn M Gao Zhenyu Z Boele Henk-Jan HJ Veloz Maria F Vinueza MF Amerika Wardell E WE Simek Antonia A M AA De Jeu Marcel T MT Steinberg Jordan P JP Takamiya Kogo K Hoebeek Freek E FE Linden David J DJ Huganir Richard L RL De Zeeuw Chris I CI

Neuron 20110401 1

Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different ...[more]

PMID: 21482355

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