Cerebellar Purkinje cell activity drives motor learning.
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ABSTRACT:
SUBMITTER: Nguyen-Vu TD
PROVIDER: S-EPMC3966616 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Cerebellar Purkinje cell activity drives motor learning.
Nguyen-Vu T D Barbara TD Kimpo Rhea R RR Rinaldi Jacob M JM Kohli Arunima A Zeng Hongkui H Deisseroth Karl K Raymond Jennifer L JL
Nature neuroscience 20131027 12
The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits. ...[more]
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