Ontology highlight
ABSTRACT:
SUBMITTER: Scott MM
PROVIDER: S-EPMC3104740 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Scott Michael M MM Williams Kevin W KW Rossi Jari J Lee Charlotte E CE Elmquist Joel K JK
The Journal of clinical investigation 20110523 6
Leptin is an adipose-derived hormone that signals to inform the brain of nutrient status; loss of leptin signaling results in marked hyperphagia and obesity. Recent work has identified several groups of neurons that contribute to the effects of leptin to regulate energy balance, but leptin receptors are distributed throughout the brain, and the function of leptin signaling in discrete neuronal populations outside of the hypothalamus has not been defined. In the current study, we produced mice in ...[more]