Ontology highlight
ABSTRACT:
SUBMITTER: Rajasekhar VK
PROVIDER: S-EPMC3105310 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nature communications 20110101
Androgen depletion is a key strategy for treating human prostate cancer, but the presence of hormone-independent cells escaping treatment remains a major therapeutic challenge. Here, we identify a minor subset of stem-like human prostate tumour-initiating cells (TICs) that do not express prostate cancer markers, such as androgen receptor or prostate specific antigen. These TICs possess stem cell characteristics and multipotency as demonstrated by in vitro sphere-formation and in vivo tumour-init ...[more]