Ontology highlight
ABSTRACT:
SUBMITTER: Tatsumi K
PROVIDER: S-EPMC3105337 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Tatsumi Kanako K Yamamoto-Mukai Harumi H Shimizu Ritsuko R Waguri Satoshi S Sou Yu-Shin YS Sakamoto Ayako A Taya Choji C Shitara Hiroshi H Hara Takahiko T Chung Chin Ha CH Tanaka Keiji K Yamamoto Masayuki M Komatsu Masaaki M
Nature communications 20110208
Post-translational protein modifications are systems designed to expand restricted genomic information through functional conversion of target molecules. Ubiquitin-like post-translational modifiers regulate numerous cellular events through their covalent linkages to target protein(s) by an enzymatic cascade analogous to ubiquitylation consisting of E1 (activating), E2 (conjugating) and E3 (ligating) enzymes. In this study, we report the essential role of Uba5, a specific activating enzyme for th ...[more]