Ontology highlight
ABSTRACT:
SUBMITTER: Peixeiro I
PROVIDER: S-EPMC3105653 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Peixeiro Isabel I Silva Ana Luísa AL Romão Luísa L
Haematologica 20110228 6
Messenger RNA (mRNA) stability is a critical determinant that affects gene expression. Many pathways have evolved to modulate mRNA stability in response to developmental, physiological and/or environmental stimuli. Eukaryotic mRNAs have a considerable range of half-lives, from as short as a few minutes to as long as several days. Human globin mRNAs constitute an example of highly stable mRNAs. However, a wide variety of naturally occurring mutations that result in the clinical syndrome of thalas ...[more]