Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5733236 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
BioMed research international 20171128
<h4>Background</h4>Fetal hemoglobin (HbF; <i>α</i><sub>2</sub><i>γ</i><sub>2</sub>) is a potent genetic modifier of the severity of <i>β</i>-thalassemia and sickle cell anemia. Differences in the levels of HbF that persist into adulthood affect the severity of sickle cell disease and the <i>β</i>-thalassemia syndromes. Sry type HMG box (SOX6) is a potent silencer of HbF. Here, we reactivated <i>γ</i>-globin expression by downregulating SOX6 to alleviate anemia in the <i>β</i>-thalassemia patient ...[more]