Ontology highlight
ABSTRACT:
SUBMITTER: Fitch RW
PROVIDER: S-EPMC3107123 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Journal of natural products 20090201 2
In 2003, we reported the isolation, structure elucidation, and pharmacology of epiquinamide (1), a novel alkaloid isolated from an Ecuadoran poison frog, Epipedobates tricolor. Since then, several groups, including ours, have undertaken synthetic efforts to produce this compound, which appeared initially to be a novel, beta2-selective nicotinic acetylcholine receptor agonist. Based on prior chiral GC analysis of synthetic and natural samples, the absolute structure of this alkaloid was establish ...[more]