Ontology highlight
ABSTRACT:
SUBMITTER: Rygh CB
PROVIDER: S-EPMC3107124 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Rygh Cecilie B CB Qin Shengping S Seo Jai W JW Mahakian Lisa M LM Zhang Hua H Adamson Roger R Chen Jane Q JQ Borowsky Alexander D AD Cardiff Robert D RD Reed Rolf K RK Curry Fitz-Roy E FR Ferrara Katherine W KW
Clinical cancer research : an official journal of the American Association for Cancer Research 20101124 3
<h4>Purpose</h4>We apply positron emission tomography (PET) to elucidate changes in nanocarrier extravasation during the transition from premalignant to malignant cancer, providing insight into the use of imaging to characterize early cancerous lesions and the utility of nanoparticles in early disease.<h4>Experimental design</h4>Albumin and liposomes were labeled with (64)Cu (half-life 12.7 hours), and longitudinal PET and CT imaging studies were conducted in a mouse model of ductal carcinoma in ...[more]