Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3107281 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Li Yang Y Zaydman Mark A MA Wu Dick D Shi Jingyi J Guan Michael M Virgin-Downey Brett B Cui Jianmin J
Proceedings of the National Academy of Sciences of the United States of America 20110516 22
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is necessary for the function of various ion channels. The potassium channel, I(Ks), is important for cardiac repolarization and requires PIP(2) to activate. Here we show that the auxiliary subunit of I(Ks), KCNE1, increases PIP(2) sensitivity 100-fold over channels formed by the pore-forming KCNQ1 subunits alone, which effectively amplifies current because native PIP(2) levels in the membrane are insufficient to activate all KCNQ1 channels. A juxta ...[more]