Ontology highlight
ABSTRACT:
SUBMITTER: Schulte B
PROVIDER: S-EPMC3795243 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Schulte Bianca B John Isabel I Simon Bernd B Brockmann Christoph C Oelmeier Stefan A SA Jahraus Beate B Kirchgessner Henning H Riplinger Selina S Carlomagno Teresa T Wabnitz Guido H GH Samstag Yvonne Y
The Journal of biological chemistry 20130903 41
Oxidative stress can lead to T cell hyporesponsiveness. A reducing micromilieu (e.g. provided by dendritic cells) can rescue T cells from such oxidant-induced dysfunction. However, the reducing effects on proteins leading to restored T cell activation remained unknown. One key molecule of T cell activation is the actin-remodeling protein cofilin, which is dephosphorylated on serine 3 upon T cell costimulation and has an essential role in formation of mature immune synapses between T cells and an ...[more]