The origin of cholesterol's condensing effect.
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ABSTRACT:
SUBMITTER: Daly TA
PROVIDER: S-EPMC3107356 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
The origin of cholesterol's condensing effect.
Daly Trevor A TA Wang Minghui M Regen Steven L SL
Langmuir : the ACS journal of surfaces and colloids 20110214 6
The condensing effect of cholesterol on fluid bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine has been compared with that of dihydrocholesterol and coprostanol by means of nearest-neighbor recognition measurements. Whereas dihydrocholesterol exhibits a condensing power that is equivalent to that of cholesterol, the action of coprostanol is significantly weaker. These results provide strong support for a template mechanism of condensation and argue against an umbrella mechanism. ...[more]
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