Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC3108241 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Zhao Yong Y Abreu Eladio E Kim Jinyong J Stadler Guido G Eskiocak Ugur U Terns Michael P MP Terns Rebecca M RM Shay Jerry W JW Wright Woodring E WE
Molecular cell 20110501 3
Specific information about how telomerase acts in vivo is necessary for understanding telomere dynamics in human tumor cells. Our results imply that, under homeostatic telomere length-maintenance conditions, only one molecule of telomerase acts at each telomere during every cell division and processively adds ∼60 nt to each end. In contrast, multiple molecules of telomerase act at each telomere when telomeres are elongating (nonequilibrium conditions). Telomerase extension is less processive dur ...[more]