Ontology highlight
ABSTRACT:
SUBMITTER: Valenzuela JC
PROVIDER: S-EPMC4173291 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Valenzuela Juan Carlos JC Heise Christopher C Franken Gilbert G Singh Jeet J Schweitzer Barbara B Seidenbecher Constanze I CI Frischknecht Renato R
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20141001 1654
Neuronal networks are balanced by mechanisms of homeostatic plasticity, which adjusts synaptic strength via molecular and morphological changes in the pre- and post-synapse. Here, we wondered whether the hyaluronic acid-based extracellular matrix (ECM) of the brain is involved in mechanisms of homeostatic plasticity. We hypothesized that the ECM, being rich in chondroitin sulfate proteoglycans such as brevican, which are suggested to stabilize synapses by their inhibitory effect on structural pl ...[more]