Hierarchical clustering of shotgun proteomics data.
Ontology highlight
ABSTRACT:
SUBMITTER: Koskinen VR
PROVIDER: S-EPMC3108832 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Hierarchical clustering of shotgun proteomics data.
Koskinen Ville R VR Emery Patrick A PA Creasy David M DM Cottrell John S JS
Molecular & cellular proteomics : MCP 20110329 6
A new result report for Mascot search results is described. A greedy set cover algorithm is used to create a minimal set of proteins, which is then grouped into families on the basis of shared peptide matches. Protein families with multiple members are represented by dendrograms, generated by hierarchical clustering using the score of the nonshared peptide matches as a distance metric. The peptide matches to the proteins in a family can be compared side by side to assess the experimental evidenc ...[more]
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