Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida T
PROVIDER: S-EPMC3109345 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Yoshida Takeshi T Kao Sandra S Strebel Klaus K
Frontiers in microbiology 20110218
The HIV-1 Vpu protein enhances the release of viral particles from the cell-surface in a cell-type specific manner. In the absence of Vpu, nascent virions remain tethered to the cell-surface in restricted cell-types. Recently, the human host factor BST-2/CD317/tetherin was found to be responsible for the inhibition of virus release. It was also reported that HIV-1 Vpu can target human BST-2 but is unable to interfere with the function of murine or simian BST-2. We performed a gain-of-function st ...[more]