Directing systemic oncolytic viral delivery to tumors via carrier cells.
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ABSTRACT:
SUBMITTER: Nakashima H
PROVIDER: S-EPMC3109423 | biostudies-literature | 2010 Apr-Jun
REPOSITORIES: biostudies-literature
Publications
Directing systemic oncolytic viral delivery to tumors via carrier cells.
Nakashima Hiroshi H Kaur Balveen B Chiocca E A EA
Cytokine & growth factor reviews 20100311 2-3
The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesenchymal and neural stem cells have been described to possess tumor-homing ability as well as the capacity to deliver OVs. In this review, we will focus on approaches where OV and carrier cells are uti ...[more]
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