Ontology highlight
ABSTRACT:
SUBMITTER: Nakashima H
PROVIDER: S-EPMC3109423 | biostudies-literature | 2010 Apr-Jun
REPOSITORIES: biostudies-literature
Cytokine & growth factor reviews 20100311 2-3
The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesenchymal and neural stem cells have been described to possess tumor-homing ability as well as the capacity to deliver OVs. In this review, we will focus on approaches where OV and carrier cells are uti ...[more]