Ontology highlight
ABSTRACT:
SUBMITTER: Yoo JY
PROVIDER: S-EPMC3784008 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Yoo Ji Young JY Pradarelli Jason J Haseley Amy A Wojton Jeffrey J Kaka Azeem A Bratasz Anna A Alvarez-Breckenridge Christopher A CA Yu Jun-Ge JG Powell Kimerly K Mazar Andrew P AP Teknos Theodoros N TN Chiocca E Antonio EA Glorioso Joseph C JC Old Matthew M Kaur Balveen B
Clinical cancer research : an official journal of the American Association for Cancer Research 20120702 18
<h4>Purpose</h4>Copper in serum supports angiogenesis and inhibits replication of wild-type HSV-1. Copper chelation is currently being investigated as an antiangiogenic and antineoplastic agent in patients diagnosed with cancer. Herpes simplex virus-derived oncolytic viruses (oHSV) are being evaluated for safety and efficacy in patients, but several host barriers limit their efficacy. Here, we tested whether copper inhibits oHSV infection and replication and whether copper chelation would augmen ...[more]