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Phylogenesis and Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection.

ABSTRACT: During the spring of 2009, a new influenza A (H1N1) virus of swine origin emerged and spread worldwide causing a pandemic influenza. Here, 329 naso-pharyngeal swabs collected from patients with flu-like symptoms were analyzed by real-time PCR for the presence of H1N1 2009 pandemic virus. Twenty-five samples collected from immunocompetent and immunodepressed patients contained the H1N1 pandemic virus. Phylogenetic analysis of the hemagglutinin and neuraminidase genes showed no obvious differences in terms of similarity and/or homology between the sequences identified in immunocompetent individuals and those obtained from immunocompromised patients. Pre-existing clinical conditions may influence the outcome of H1N1 disease.

SUBMITTER: Ciccozzi M

PROVIDER: S-EPMC3109524 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Phylogenesis and Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection.

Ciccozzi Massimo M Babakir-Mina Muhammed M Lo Presti Alessandra A Marcuccilli Fabbio F Perno Carlo Federico CF Ciotti Marco M

The open virology journal 20110407

During the spring of 2009, a new influenza A (H1N1) virus of swine origin emerged and spread worldwide causing a pandemic influenza. Here, 329 naso-pharyngeal swabs collected from patients with flu-like symptoms were analyzed by real-time PCR for the presence of H1N1 2009 pandemic virus. Twenty-five samples collected from immunocompetent and immunodepressed patients contained the H1N1 pandemic virus. Phylogenetic analysis of the hemagglutinin and neuraminidase genes showed no obvious differences ...[more]

PMID: 21660186

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