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Analysis of the beta-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque.

ABSTRACT: Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusibeta-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The beta-tubulin of E. bieneusi has a substitution at Glu(198), which is one of six amino acids reported to be associated with benzimidazole sensitivity.

SUBMITTER: Akiyoshi DE

PROVIDER: S-EPMC3109643 | biostudies-literature | 2007 Jan-Feb

REPOSITORIES: biostudies-literature

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Analysis of the beta-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque.

Akiyoshi Donna E DE Weiss Louis M LM Feng Xiaochuan X Williams Bryony A P BA Keeling Patrick J PJ Zhang Quanshun Q Tzipori Saul S

The Journal of eukaryotic microbiology 20070101 1

Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusibeta-tubulin from isolates from an infected human and a nat ...[more]

PMID: 17300517

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Epidemiological investigation and genotypes of Enterocytozoon bieneusi in 11 captive Rhesus macaque populations.

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