Ontology highlight
ABSTRACT:
SUBMITTER: Kwon ES
PROVIDER: S-EPMC3109862 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Kwon Eun-Soo ES Narasimhan Sri Devi SD Yen Kelvin K Tissenbaum Heidi A HA
Nature 20100707 7305
The insulin/IGF-1 signalling (IIS) pathway has diverse roles from metabolism to longevity. In Caenorhabditis elegans, the single forkhead box O (FOXO) homologue, DAF-16, functions as the major target of the IIS pathway. One of two isoforms, DAF-16a, is known to regulate longevity, stress response and dauer diapause. However, it remains unclear how DAF-16 achieves its specificity in regulating these various biological processes. Here we identify a new isoform, DAF-16d/f, as an important isoform r ...[more]