Ontology highlight
ABSTRACT:
SUBMITTER: Qi Z
PROVIDER: S-EPMC7880325 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Qi Zhimin Z Ji Huihui H Le Monika M Li Hanmei H Wieland Angela A Bauer Sonja S Liu Li L Wink Michael M Herr Ingrid I
Aging 20210120 2
The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the <i>C. elegans</i> nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin accumulation, and RNA and protein expression of the nematodes were assessed by using Kaplan-Meier survival analysis, <i>in vivo</i> live imaging, fluorescence microscopy, and ...[more]