Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
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ABSTRACT:
SUBMITTER: Sromek AW
PROVIDER: S-EPMC3110009 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
Sromek Anna W AW Si Yu-Gui YG Zhang Tangzhi T George Susan R SR Seeman Philip P Neumeyer John L JL
ACS medicinal chemistry letters 20110301 3
The 2-fluoroalkoxy substituted catechol-aporphines 6, 8a-f and 11-monohydroxyaporphines 11a-e were synthesized and found to have high in vitro affinity and selectivity for the dopamine D(2) receptors. The catechol aporphines, 8b and 8d, and the monohydroxy aporphines, 11a-d, were identified as candidates for development as potential PET ligands. ...[more]
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