Predicting deleterious amino acid substitutions.
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ABSTRACT:
SUBMITTER: Ng PC
PROVIDER: S-EPMC311071 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Publications
Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology to predict whether a substitution affects protein function. SIFT, which sorts intolerant from tolerant substitutions, classifies substitutions as tolerated or deleterious. A higher proportion of substitutions predicted to be deleterious by SIFT ...[more]
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