Superelectrophilic chemistry of amino-nitriles and related substrates.
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ABSTRACT:
SUBMITTER: Raja EK
PROVIDER: S-EPMC3110710 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Superelectrophilic chemistry of amino-nitriles and related substrates.
Raja Erum K EK Klumpp Douglas A DA
Tetrahedron 20110601 25
The superacid-promoted Houben-Hoesch reactions of amino-nitriles and related compounds have been studied. The nitriles form dicationic electrophiles and react with benzene in fair to good yields (12-95%). The intermediate iminium ions may also be reduced to the benzylic amines by NaBH(4) or H(2). ...[more]
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