Ontology highlight
ABSTRACT:
SUBMITTER: Naredla RR
PROVIDER: S-EPMC3775391 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Naredla Rajasekhar Reddy RR Raja Erum K EK Klumpp Douglas A DA
Tetrahedron letters 20130601 25
A series of pyridyl-substituted 3-hydroxy-2-oxyindoles have been prepared and reacted with arenes in superacid promoted Friedel-Crafts reactions. The product aryl-substituted 2-oxyindoles are formed in generally good yields. With substituted arenes such as toluene, bromobenzene, or ethyl salicylate, the Friedel-Crafts reactions occur with excellent regioselectivity. A mechanism is proposed involving dicationic, superelectrophilic species leading to the electrophilic aromatic substitution chemist ...[more]