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Wnt modulators in the biotech pipeline.

ABSTRACT: The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.

SUBMITTER: Rey JP 

PROVIDER: S-EPMC3111251 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Wnt modulators in the biotech pipeline.

Rey Jean-Philippe JP   Ellies Debra L DL  

Developmental dynamics : an official publication of the American Association of Anatomists 20100101 1

The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP. ...[more]

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