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Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0.

ABSTRACT: The increasing discoveries regarding the biology and functions of platelets in the last decade undoubtedly show that these cells are one of the most biotechnological human cells. This review summarizes new advances in platelet biology, functions, and new concepts of biotech-educated platelets that connect advanced biomimetic science to platelet-based additive manufacturing for tissue regeneration. As highly responsive and secretory cells, platelets could be explored to develop solutions that alter injured microenvironments through platelet-based synthetic biomaterials with instructive extracellular cues for morphogenesis in tissue engineering beyond tissue regeneration 2.0.

SUBMITTER: Andrade SS

PROVIDER: S-EPMC7503652 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0.

Andrade Sheila Siqueira SS Faria Alessandra Valéria de Sousa AVS Girão Manoel João Batista C MJBC Fuhler Gwenny M GM Peppelenbosch Maikel P MP Ferreira-Halder Carmen V CV

International journal of molecular sciences 20200823 17

The increasing discoveries regarding the biology and functions of platelets in the last decade undoubtedly show that these cells are one of the most biotechnological human cells. This review summarizes new advances in platelet biology, functions, and new concepts of biotech-educated platelets that connect advanced biomimetic science to platelet-based additive manufacturing for tissue regeneration. As highly responsive and secretory cells, platelets could be explored to develop solutions that alt ...[more]

PMID: 32842455

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