Ontology highlight
ABSTRACT:
SUBMITTER: Christoffersen C
PROVIDER: S-EPMC3111292 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Christoffersen Christina C Obinata Hideru H Kumaraswamy Sunil B SB Galvani Sylvain S Ahnström Josefin J Sevvana Madhumati M Egerer-Sieber Claudia C Muller Yves A YA Hla Timothy T Nielsen Lars B LB Dahlbäck Björn B
Proceedings of the National Academy of Sciences of the United States of America 20110523 23
Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did not. Moreover, HDL in Apom(-/-) mice contains no S1P, whereas HDL in transgenic mice overexpressing human apoM has an increased S1P content. The 1.7-Å structure of the S1P-human apoM complex reveals t ...[more]