Ontology highlight
ABSTRACT:
SUBMITTER: Normand S
PROVIDER: S-EPMC3111299 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Normand Sylvain S Delanoye-Crespin Anne A Bressenot Aude A Huot Ludovic L Grandjean Teddy T Peyrin-Biroulet Laurent L Lemoine Yves Y Hot David D Chamaillard Mathias M
Proceedings of the National Academy of Sciences of the United States of America 20110518 23
The colonic epithelium self-renews every 3 to 5 d, but our understanding of the underlying processes preserving wound healing from carcinogenesis remains incomplete. Here, we demonstrate that Nod-like receptor pyrin domain-containing protein 6 (NLRP6) suppresses inflammation and carcinogenesis by regulating tissue repair. NLRP6 was primarily produced by myofibroblasts within the stem-cell niche in the colon. Although NLRP6 expression was lowered in diseased colon, NLRP6-deficient mice were highl ...[more]