Ontology highlight
ABSTRACT:
SUBMITTER: Miyata N
PROVIDER: S-EPMC6177233 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cell reports 20180801 9
Physiologic microbe-host interactions in the intestine require the maintenance of the microbiota in a luminal compartment through a complex interplay between epithelial and immune cells. However, the roles of mucosal myeloid cells in this process remain incompletely understood. In this study, we identified that decreased myeloid cell phagocytic activity promotes colon tumorigenesis. We show that this is due to bacterial accumulation in the lamina propria and present evidence that the underlying ...[more]