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Preparation of a versatile bifunctional zeolite for targeted imaging applications.

ABSTRACT: Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecular targeting vectors (e.g., peptides, aptamers) to the zeolite surface. The modified particle efficiently incorporates the imaging radioisotope gallium-68 ((68)Ga) into the pores of the azide-functionalized NaY zeolite to form a stable bifunctional molecular targeting vector. The result is a versatile "clickable" zeolite platform that can be tailored for future in vivo molecular targeting and imaging modalities.

SUBMITTER: Ndiege N

PROVIDER: S-EPMC3112301 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Preparation of a versatile bifunctional zeolite for targeted imaging applications.

Ndiege Nicholas N Raidoo Renugan R Schultz Michael K MK Larsen Sarah S

Langmuir : the ACS journal of surfaces and colloids 20110209 6

Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecul ...[more]

PMID: 21306141

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