Unknown

Dataset Information

0

Preparation of a versatile bifunctional zeolite for targeted imaging applications.


ABSTRACT: Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecular targeting vectors (e.g., peptides, aptamers) to the zeolite surface. The modified particle efficiently incorporates the imaging radioisotope gallium-68 ((68)Ga) into the pores of the azide-functionalized NaY zeolite to form a stable bifunctional molecular targeting vector. The result is a versatile "clickable" zeolite platform that can be tailored for future in vivo molecular targeting and imaging modalities.

SUBMITTER: Ndiege N 

PROVIDER: S-EPMC3112301 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Preparation of a versatile bifunctional zeolite for targeted imaging applications.

Ndiege Nicholas N   Raidoo Renugan R   Schultz Michael K MK   Larsen Sarah S  

Langmuir : the ACS journal of surfaces and colloids 20110209 6


Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecul  ...[more]

Similar Datasets

| S-EPMC5830459 | biostudies-literature
| S-EPMC3133935 | biostudies-literature
| S-EPMC8708772 | biostudies-literature
| S-EPMC4948596 | biostudies-literature
| S-EPMC2678937 | biostudies-literature
| S-EPMC4410081 | biostudies-literature
| S-EPMC8174103 | biostudies-literature
| S-EPMC6129851 | biostudies-literature
| S-EPMC5330650 | biostudies-literature
| S-EPMC6774382 | biostudies-literature