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Structure of estradiol metal chelate and estrogen receptor complex: the basis for designing a new class of selective estrogen receptor modulators.

ABSTRACT: Selective estrogen receptor modulators, such as 17?-estradiol derivatives bound to metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor ? ligand-binding domain (ER?-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridine tetra acetate europium(III), at 2.6 Å resolution. This structure provides important information pertinent to the design of novel functional ER? targeted probes for clinical applications.

SUBMITTER: Li MJ

PROVIDER: S-EPMC3112352 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Structure of estradiol metal chelate and estrogen receptor complex: the basis for designing a new class of selective estrogen receptor modulators.

Li Min-Jun MJ Greenblatt Harry M HM Dym Orly O Albeck Shira S Pais Adi A Gunanathan Chidambaram C Milstein David D Degani Hadassa H Sussman Joel L JL

Journal of medicinal chemistry 20110419 10

Selective estrogen receptor modulators, such as 17β-estradiol derivatives bound to metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor α ligand-binding domain (ERα-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridine tetra acetate europium(III), at 2.6 Å resolution. This structure provides important information pertinent to the design of novel functional E ...[more]

PMID: 21473635

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