Ontology highlight
ABSTRACT:
SUBMITTER: Saurin AT
PROVIDER: S-EPMC3113227 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Nature communications 20110101
The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect attachments; however, a more direct role remains controversial. In contrast, activity of the kinase Mps1 is indispensible for the mitotic checkpoint. Here we show that Aurora B and Hec1 are needed for efficient Mps1 recruitment to unattached kinetochores, allowing rapid Mps1 activation at the onset of mitosis. Live ...[more]