Dosimetry of 18F-labeled tyrosine kinase inhibitor SKI-249380, a dasatinib-tracer for PET imaging.
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ABSTRACT:
SUBMITTER: Dunphy MP
PROVIDER: S-EPMC3113455 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Dosimetry of 18F-labeled tyrosine kinase inhibitor SKI-249380, a dasatinib-tracer for PET imaging.
Dunphy Mark P S MP Zanzonico Pat P Veach Darren D Somwar Romel R Pillarsetty Nagavarakishore N Lewis Jason J Larson Steven S
Molecular imaging and biology 20120201 1
<h4>Purpose</h4>To obtain estimates of human normal-organ radiation doses of ¹⁸F-SKI-249380, as a prerequisite step towards first-in-human trial. ¹⁸F-SKI-249380 is a first-of-its-kind PET tracer for imaging the in vivo pharmacokinetics of dasatinib, an investigational targeted therapy for solid malignancies.<h4>Procedures</h4>Isoflurane-anesthetized mice received tracer dose via tail vein. Organ time-integrated activity coefficients, fractional urinary and hepatobiliary excretion, and total-body ...[more]
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