Ontology highlight
ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC3114196 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Chen R R Stahl E A EA Kurreeman F A S FA Gregersen P K PK Siminovitch K A KA Worthington J J Padyukov L L Raychaudhuri S S Plenge R M RM
Genes and immunity 20110310 4
A common allele at the TAGAP gene locus demonstrates a suggestive, but not conclusive association with risk of rheumatoid arthritis (RA). To fine map the locus, we conducted comprehensive imputation of CEU HapMap single-nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) of 5,500 RA cases and 22,621 controls (all of European ancestry). After controlling for population stratification with principal components analysis, the strongest signal of association was to an imputed SN ...[more]