Ontology highlight
ABSTRACT:
SUBMITTER: Westra HJ
PROVIDER: S-EPMC6364548 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Westra Harm-Jan HJ Martínez-Bonet Marta M Onengut-Gumuscu Suna S Lee Annette A Luo Yang Y Teslovich Nikola N Worthington Jane J Martin Javier J Huizinga Tom T Klareskog Lars L Rantapaa-Dahlqvist Solbritt S Chen Wei-Min WM Quinlan Aaron A Todd John A JA Eyre Steve S Nigrovic Peter A PA Gregersen Peter K PK Rich Stephen S SS Raychaudhuri Soumya S
Nature genetics 20180917 10
To define potentially causal variants for autoimmune disease, we fine-mapped<sup>1,2</sup> 76 rheumatoid arthritis (11,475 cases, 15,870 controls)<sup>3</sup> and type 1 diabetes loci (9,334 cases, 11,111 controls)<sup>4</sup>. After sequencing 799 1-kilobase regulatory (H3K4me3) regions within these loci in 568 individuals, we observed accurate imputation for 89% of common variants. We defined credible sets of ≤5 causal variants at 5 rheumatoid arthritis and 10 type 1 diabetes loci. We identifi ...[more]