Ontology highlight
ABSTRACT:
SUBMITTER: Walsh LA
PROVIDER: S-EPMC3114285 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Walsh Logan A LA Nawshad Ali A Medici Damian D
Matrix biology : journal of the International Society for Matrix Biology 20110406 4
Discoidin domain receptor 2 (DDR2) is a collagen receptor that is expressed during epithelial-mesenchymal transition (EMT), a cellular transformation that mediates many stages of embryonic development and disease. However, the functional significance of this receptor in EMT is unknown. Here we show that Transforming Growth Factor-beta1 (TGF-β1), a common stimulator of EMT, promotes increased expression of type I collagen and DDR2. Inhibiting expression of COL1A1 or DDR2 with siRNA is sufficient ...[more]