ZEB2, a master regulator of the epithelial-mesenchymal transition, mediates trophoblast differentiation.

ABSTRACT:

Study question

Does the upregulation of the zinc finger E-box binding homeobox 2 (ZEB2) transcription factor in human trophoblast cells lead to alterations in gene expression consistent with an epithelial-mesenchymal transition (EMT) and a consequent increase in invasiveness?

Summary answer

Overexpression of ZEB2 results in an epithelial-mesenchymal shift in gene expression accompanied by a substantial increase in the invasive capacity of human trophoblast cells.

What is known already

In-vivo results have shown that cytotrophoblast differentiation into extravillous trophoblast involves an epithelial-mesenchymal transition. The only EMT master regulatory factor which shows changes consistent with extravillous trophoblast EMT status and invasive capacity is the ZEB2 tra

SUBMITTER: DaSilva-Arnold SC 

PROVIDER: S-EPMC6497037 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature