High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3114948 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
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High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses.
Li Yanhong Y Cao Hongzhi H Dao Nguyet N Luo Zheng Z Yu Hai H Chen Yi Y Xing Zheng Z Baumgarth Nicole N Cardona Carol C Chen Xi X
Virology 20110417 1
Despite the importance of neuraminidase (NA) activity in effective infection by influenza A viruses, limited information exists about the differences of substrate preferences of viral neuraminidases from different hosts or from different strains. Using a high-throughput screening format and a library of twenty α2-3- or α2-6-linked para-nitrophenol-tagged sialylgalactosides, substrate specificity of NAs on thirty-seven strains of human and avian influenza A viruses was studied using intact viral ...[more]
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