Ontology highlight
ABSTRACT:
SUBMITTER: Mir SE
PROVIDER: S-EPMC3115571 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Mir Shahryar E SE De Witt Hamer Philip C PC Krawczyk Przemek M PM Balaj Leonora L Claes An A Niers Johanna M JM Van Tilborg Angela A G AA Zwinderman Aeilko H AH Geerts Dirk D Kaspers Gertjan J L GJ Peter Vandertop W W Cloos Jacqueline J Tannous Bakhos A BA Wesseling Pieter P Aten Jacob A JA Noske David P DP Van Noorden Cornelis J F CJ Würdinger Thomas T
Cancer cell 20100901 3
Kinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment. Here we analyze the kinase gene expression profiles of various tumor types and reveal the wee1 kinase to be overexpressed in glioblastomas. We demonstrate that WEE1 is a major regulator of the G(2) checkpoint in glioblastoma cells. Inhibition of WEE1 by siRNA or small molecular compound in cells exposed to DNA damaging agents results in abrogation of the G(2) arrest, pre ...[more]